A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid

A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid

Abstract Synthetic auxotrophy in which cell viability depends on the presence of an unnatural amino acid (unAA) provides a powerful strategy to restrict unwanted propagation of genetically modified organisms (GMOs) in open environments and potentially prevent industrial espionage. Here, we describe...

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Bibliographic Details
Main Authors: Tiantian Chang, Weichao Ding, Shirui Yan, Yun Wang, Haoling Zhang, Yu Zhang, Zhi Ping, Huiming Zhang, Yijian Huang, Jiahui Zhang, Dan Wang, Wenwei Zhang, Xun Xu, Yue Shen, Xian Fu
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42358-4

Internet

https://doi.org/10.1038/s41467-023-42358-4

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