A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid
Abstract Synthetic auxotrophy in which cell viability depends on the presence of an unnatural amino acid (unAA) provides a powerful strategy to restrict unwanted propagation of genetically modified organisms (GMOs) in open environments and potentially prevent industrial espionage. Here, we describe...
Main Authors: | Tiantian Chang, Weichao Ding, Shirui Yan, Yun Wang, Haoling Zhang, Yu Zhang, Zhi Ping, Huiming Zhang, Yijian Huang, Jiahui Zhang, Dan Wang, Wenwei Zhang, Xun Xu, Yue Shen, Xian Fu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-42358-4 |
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