The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the mitochondrial membrane by a carboxyl-terminal seque...

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Bibliographic Details
Main Authors: Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
primary murine neurons
MEF cells
BMK cells
apoptosis
Bcl-2 family proteins
mitochondrial outer membrane permeabilization
Online Access:https://elifesciences.org/articles/44525

Internet

https://elifesciences.org/articles/44525

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