An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein

Summary: The foot-and-mouth disease virus (FMDV) 2C protein shares conserved motifs with enterovirus 2Cs despite low sequence identity. Here, we determine the crystal structure of an FMDV 2C fragment to 1.83 Å resolution, which comprises an ATPase domain, a region equivalent to the enterovirus 2C zi...

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Bibliographic Details
Main Authors: Chu Zhang, Fan Yang, Justyna Aleksandra Wojdyla, Bo Qin, Wei Zhang, Min Zheng, Weijun Cao, Meitian Wang, Xiaopan Gao, Haixue Zheng, Sheng Cui
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722008245