Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas

Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas

Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of less than 15 months. Radiotherapy has been the mainstay of treatment of HGGs for dec...

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Bibliographic Details
Main Authors: Faiqa Mudassar, Han Shen, Geraldine O’Neill, Eric Hau
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
High-grade gliomas
Radioresistance
Hypoxia
HIFs
Mitochondria
Metabolism
Online Access:http://link.springer.com/article/10.1186/s13046-020-01724-6

Internet

http://link.springer.com/article/10.1186/s13046-020-01724-6

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