NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17218-0 |
| _version_ | 1818682391328194560 |
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| author | Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang |
| author_facet | Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang |
| author_sort | Myung-Kyu Choi |
| collection | DOAJ |
| description | Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans. |
| first_indexed | 2024-12-17T10:18:06Z |
| format | Article |
| id | doaj.art-39398b289a3b4e4591f7870378ecd1af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:18:06Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-39398b289a3b4e4591f7870378ecd1af2022-12-21T21:52:52ZengNature PortfolioNature Communications2041-17232020-07-0111111610.1038/s41467-020-17218-0NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegansMyung-Kyu Choi0He Liu1Taihong Wu2Wenxing Yang3Yun Zhang4Department of Organismic and Evolutionary Biology, Harvard UniversityDepartment of Organismic and Evolutionary Biology, Harvard UniversityDepartment of Organismic and Evolutionary Biology, Harvard UniversityDepartment of Organismic and Evolutionary Biology, Harvard UniversityDepartment of Organismic and Evolutionary Biology, Harvard UniversityNeural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.https://doi.org/10.1038/s41467-020-17218-0 |
| spellingShingle | Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans Nature Communications |
| title | NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans |
| title_full | NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans |
| title_fullStr | NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans |
| title_full_unstemmed | NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans |
| title_short | NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans |
| title_sort | nmdar mediated modulation of gap junction circuit regulates olfactory learning in c elegans |
| url | https://doi.org/10.1038/s41467-020-17218-0 |
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