Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia

Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia

Apoptosis of cells at the site of infection is a requirement for shutdown of inflammatory signaling, avoiding tissue damage, and preventing progression of sepsis. Puma+/+ and Puma-/- mice were challenged with TIGR4 strain pneumococcus and cytokines were quantitated from lungs and blood using a magne...

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Bibliographic Details
Main Authors: Daniel E. Kennedy II, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
PUMA (p53 upregulated modulator of apoptosis)
inflammation
streptococcus pneumoniae (pneumococcus)
apoptosis
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.886901/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.886901/full

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