Structural mechanisms for VMAT2 inhibition by tetrabenazine
The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s disease and schizophrenia. Furthermore, drugs such as...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/91973 |