A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism of oral DMT, ayahuasca preparations additionally contain reversi...

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Bibliographic Details
Main Authors: Klemens Egger, Frederik Gudmundsen, Naja Støckel Jessen, Christina Baun, Sandra N. Poetzsch, Vladimir Shalgunov, Matthias M. Herth, Boris B. Quednow, Chantal Martin-Soelch, Dario Dornbierer, Milan Scheidegger, Paul Cumming, Mikael Palner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
psychedelics
ayahuasca
pharmahuasca
DMT
harmine
serotonin receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1140656/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1140656/full

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