MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

Abstract Background An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted transforming growth factor beta (TGF-β) participated in the immune modu...

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Bibliographic Details
Main Authors: Feng Liu, Haibo Qiu, Ming Xue, Shi Zhang, Xiwen Zhang, Jingyuan Xu, Jianxiao Chen, Yi Yang, Jianfeng Xie
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Sepsis
Transforming growth factor beta
Mesenchymal stem cells
Macrophages
Akt/FoxO1
Online Access:http://link.springer.com/article/10.1186/s13287-019-1447-y

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http://link.springer.com/article/10.1186/s13287-019-1447-y

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