Comparative effects of hepatocyte growth factor and tacrolimus on acute liver allograft early tolerance

Comparative effects of hepatocyte growth factor and tacrolimus on acute liver allograft early tolerance

Allostimulated CD8+ T cells (aCD8+ T cells), as the main mediators of acute liver rejection (ARJ), are hyposensitive to apoptosis due to the inactivation of death receptor FAS-mediated pathways and fail to allow tolerance induction, eventually leading to acute graft rejection. Although tacrolimus (F...

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Bibliographic Details
Main Authors: Quanyu Chen, Zhiqing Yang, Heng Lin, Jiejuan Lai, Deyu Hu, Min Yan, Zhifang Wu, Wei Liu, Zhehai Li, Yu He, Zhe Sun, Ling Shuai, Zhiping Peng, Yangyang Wang, Sijin Li, Youhong Cui, Hongyu Zhang, Leida Zhang, Lianhua Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
immune tolerance
hepatocyte growth factor (HGF)
tacrolimus
liver transplantation
T lymphocytes
immunosuppressants
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1162439/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1162439/full

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