Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ubiquitination and degradation of oncoproteins. Despite this m...

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Bibliographic Details
Main Authors: Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Molecular Oncology
Subjects:
cancer
CDC7
CRISPR screen
FBXW7
synthetic lethality
Online Access:https://doi.org/10.1002/1878-0261.13537

Internet

https://doi.org/10.1002/1878-0261.13537

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