Uricase-deficient rat is generated with CRISPR/Cas9 technique

Uricase-deficient rat is generated with CRISPR/Cas9 technique

Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 te...

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Bibliographic Details
Main Authors: Yun Yu, Nan Zhang, Xianxiang Dong, Nan Fan, Lei Wang, Yuhui Xu, Huan Chen, Weigang Duan
Format: Article
Language:English
Published: PeerJ Inc. 2020-04-01
Series:PeerJ
Subjects:
Uricase-deficiency
CRISPR/Cas9 technique
Hyperuricemia
High throughput sequencing
Model animal
Renal function
Online Access:https://peerj.com/articles/8971.pdf

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https://peerj.com/articles/8971.pdf

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