Identification of IRF-associated molecular subtypes in clear cell renal cell carcinoma to characterize immunological characteristics and guide therapy

Identification of IRF-associated molecular subtypes in clear cell renal cell carcinoma to characterize immunological characteristics and guide therapy

BackgroundRecently studies have identified a critical role for interferon regulatory factor (IRF) in modulating tumour immune microenvironment (TME) infiltration and tumorigenesis.MethodsBased on IRF1-9 expression profiles, we classified all ccRCC samples into three molecular subtypes (clusters A-C)...

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Bibliographic Details
Main Authors: Can Chen, Lin-Yuan Chen, Rui-Xia Yang, Jie-Xin Zhang, Peng-Fei Shao, Hua-Guo Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
ccRCC
IRF family
tumour microenvironment
t cell exhaustion
immunotherapy
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1118472/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1118472/full

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