Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Abstract Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polygenic risk score (PRS) analysis to illustrate the new genetic architectur...

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Bibliographic Details
Main Authors: Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang, Shun-Jen Chang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Arthritis Research & Therapy
Subjects:
Gout
Hyperuricemia
Genome-wide association study
Polygenic risk score
Chromosome 1
Online Access:https://doi.org/10.1186/s13075-022-02917-4

Internet

https://doi.org/10.1186/s13075-022-02917-4

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