Mast Cell/Proteinase Activated Receptor 2 (PAR2) Mediated Interactions in the Pathogenesis of Discogenic Back Pain

Mast Cell/Proteinase Activated Receptor 2 (PAR2) Mediated Interactions in the Pathogenesis of Discogenic Back Pain

Mast cells (MCs) are present in the painful degenerate human intervertebral disc (IVD) and are associated with disease pathogenesis. MCs release granules containing enzymatic and inflammatory factors in response to stimulants or allergens. The serine protease, tryptase, is unique to MCs and its acti...

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Bibliographic Details
Main Authors: Justin Richards, Shirley Tang, Gilian Gunsch, Pavel Sul, Matthew Wiet, David C. Flanigan, Safdar N. Khan, Sarah Moore, Benjamin Walter, Devina Purmessur
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mast cell
tryptase
PAR2
intervertebral disc
discogenic back pain
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00294/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00294/full

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