New variants of alpha-1-antitrypsin: structural simulations and clinical expression

New variants of alpha-1-antitrypsin: structural simulations and clinical expression

Abstract Background Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver and lung disease. The characterization at structural level of novel pathogenic SERPINA1 mutants coding for circulating AAT could provide novel insights into...

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Bibliographic Details
Main Authors: Angel Gonzalez, Irene Belmonte, Alexa Nuñez, Georgina Farago, Miriam Barrecheguren, Mònica Pons, Gerard Orriols, Pablo Gabriel-Medina, Francisco Rodríguez-Frías, Marc Miravitlles, Cristina Esquinas
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
Alpha-1 antitrypsin deficiency
SERPINA1 novel variants
Structural mapping
Molecular dynamic simulations
Online Access:https://doi.org/10.1186/s12931-022-02271-8

Internet

https://doi.org/10.1186/s12931-022-02271-8

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