Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling

Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion and activation of peripheral regulatory T cells (Tregs) in mice. In this study, we investigated the molecula...

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Bibliographic Details
Main Authors: Zhaohua Guo, Jintao Zhang, Xuemei Liu, Jacqueline Unsinger, Richard S Hotchkiss, Yu-Qing Cao
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Neurobiology of Pain
Subjects:
Chronic migraine
Sensitization
Low-dose interleukin-2
Transforming growth factor beta-1
Interleukin-10
Trigeminal ganglion neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X22000137

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http://www.sciencedirect.com/science/article/pii/S2452073X22000137

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