Homology modeling, binding site identification, molecular docking and molecular dynamics simulation study of emerging and promising drug target of Wnt signaling – Human Porcupine enzyme

Homology modeling, binding site identification, molecular docking and molecular dynamics simulation study of emerging and promising drug target of Wnt signaling – Human Porcupine enzyme

Wnt signaling is a critical pathway involved in cell proliferation, differentiation and cellular homeostasis. To address treatment need of diseases associated with the dysregulated Wnt signaling like cancer, Alzheimer’s disease, Osteoporosis, Myocardial infarction etc.; small molecules that target t...

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Bibliographic Details
Main Authors: Vishalgiri Goswami, Dhaval Patel, Shishir Rohit, Udit Chaube, Bhumika Patel
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Porcupine
Homology modelling
Wnt signaling
Ramachandran plot
LGK-974
Molsoft ICM Pro
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624001784

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http://www.sciencedirect.com/science/article/pii/S2211715624001784

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