Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells

Abstract Cisplatin-based chemotherapy has associated clinical disadvantages, such as high toxicity and resistance. Thus, the development of new antitumor metallodrugs able to overcome different clinical barriers is a public healthcare priority. Here, we studied the mechanism of action of the isomers...

Full description

Bibliographic Details
Main Authors: Jorge Melones-Herrero, Sonia Alcalá, Laura Ruiz-Cañas, Carlos Benítez-Buelga, Sandra Batres-Ramos, Carmela Calés, Oscar Lorenzo, Rosario Perona, Adoración G. Quiroga, Bruno Sainz, Isabel Sánchez-Pérez
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06052-5