Polμ deficiency increases resistance to oxidative damage and delays liver aging.

Polμ deficiency increases resistance to oxidative damage and delays liver aging.

Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ(-/-)) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ(-/-) mice have increased learn...

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Bibliographic Details
Main Authors: Beatriz Escudero, Daniel Lucas, Carmen Albo, Suveera Dhup, Jeff W Bacher, Aránzazu Sánchez-Muñoz, Margarita Fernández, José Rivera-Torres, Rosa M Carmona, Encarnación Fuster, Candelas Carreiro, Raquel Bernad, Manuel A González, Vicente Andrés, Luis Blanco, Enrique Roche, Isabel Fabregat, Enrique Samper, Antonio Bernad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3972199?pdf=render

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http://europepmc.org/articles/PMC3972199?pdf=render

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