Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p

Abstract Background Our study aims to investigate the role and mechanism of circular RNA_0002715 (circ_0002715) in osteoarthritis (OA) progression. Methods IL-1β-induced CHON-001 cells were used to mimic OA cell model. Circ_0002715, microRNA (miR)-127-5p and Latexin (LXN) expression was detected by...

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Bibliographic Details
Main Authors: Hongbo Liu, Hongxia Zhao, Yin Huang, Ming Lei
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-023-03638-3