Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene in cancer cells may be associated with immunosuppressive tumor microenvironment (TME) and poor response to immune checkpoint blockade (ICB) therapy. Therefore, efficiently restorin...

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Bibliographic Details
Main Authors: Yongshun Zhang, Lan Yang, Yangsen Ou, Rui Hu, Guangsheng Du, Shuang Luo, Fuhua Wu, Hairui Wang, Zhiqiang Xie, Yu Zhang, Chunting He, Cheng Ma, Tao Gong, Ling Zhang, Zhirong Zhang, Xun Sun
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Triple therapy
Adeno-associated virus
PTEN
PPSG@anti-PD-1
CpG
Immunogenic cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002095

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http://www.sciencedirect.com/science/article/pii/S2211383523002095

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