Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC

Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC

RNA interference (RNAi) molecules have tremendous potential for cancer therapy but are limited by insufficient potency after intravenous (IV) administration. We previously found that polymer complexes (polyplexes) formed between 3′-cholesterol-modified siRNA (Chol-siRNA) or DsiRNA (Chol-DsiRNA) and...

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Bibliographic Details
Main Authors: Zhen Ye, Mai Mohamed Abdelmoaty, Stephen M. Curran, Shetty Ravi Dyavar, Devendra Kumar, Yazen Alnouti, Don W. Coulter, Anthony T. Podany, Rakesh K. Singh, Joseph A. Vetro
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Non-Coding RNA
Subjects:
RNAi
drug delivery
siRNA delivery
DsiRNA delivery
RNAi delivery
Chol-DsiRNA polymer micelles
Online Access:https://www.mdpi.com/2311-553X/8/1/8

Internet

https://www.mdpi.com/2311-553X/8/1/8

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