Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network

Blood monocytes mediate the hematogenous dissemination of human cytomegalovirus (HCMV) in the host. However, monocytes have a short 48-hour (h) lifespan and are not permissive for viral replication. We previously established that HCMV infection drives differentiation of monocytes into long-lived mac...

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Bibliographic Details
Main Authors: Olesea Cojohari, Jamil Mahmud, Aaron M. Altman, Megan A. Peppenelli, Michael J. Miller, Gary C. Chan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/6/652