IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins

IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins

Lysosome-targeting chimeras (LYTACs) have recently been developed to facilitate the lysosomal degradation of specific extracellular and transmembrane molecular targets. However, the LYTAC particles described to date are based on glycopeptide conjugates, which are difficult to prepare and produce on...

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Bibliographic Details
Main Authors: Michał Mikitiuk, Jan Barczyński, Przemysław Bielski, Marcelino Arciniega, Urszula Tyrcha, Aleksandra Hec, Andrea D. Lipińska, Michał Rychłowski, Tad A. Holak, Tomasz Sitar
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
LYTAC
targeted protein degradation
PD-1
PD-L1
immune checkpoint blockade
Online Access:https://www.mdpi.com/1420-3049/28/22/7519

Internet

https://www.mdpi.com/1420-3049/28/22/7519

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