Amelioration of Endotoxin-Induced Acute Lung Injury and Alveolar Epithelial Cells Apoptosis by Simvastatin Is Associated with Up-Regulation of Survivin/NF-<span style="font-variant: small-caps">k</span>B/p65 Pathway

Amelioration of Endotoxin-Induced Acute Lung Injury and Alveolar Epithelial Cells Apoptosis by Simvastatin Is Associated with Up-Regulation of Survivin/NF-<span style="font-variant: small-caps">k</span>B/p65 Pathway

Disruption of the alveolar–endothelial barrier caused by inflammation leads to the progression of septic acute lung injury (ALI). In the present study, we investigated the beneficial effects of simvastatin on the endotoxin lipopolysaccharide (LPS)-induced ALI and its related mechanisms. A model of A...

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Bibliographic Details
Main Authors: Lana Nežić, Ljiljana Amidžić, Ranko Škrbić, Radoslav Gajanin, Danijela Mandić, Jelena Dumanović, Zoran Milovanović, Vesna Jaćević
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
simvastatin
alveolar epithelial cells
apoptosis
survivin
NF-<span style="font-variant: small-caps">k</span>B/p65
Online Access:https://www.mdpi.com/1422-0067/23/5/2596

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https://www.mdpi.com/1422-0067/23/5/2596

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