Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resistance to NAMPT inhibition in several tumor types wh...

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Bibliographic Details
Main Authors: Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V. Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
NAPRT inhibitors
NAD biosynthesis
Preiss–Handler pathway
OVCAR-5
bioactive molecules
NAMPT
Online Access:https://www.mdpi.com/1424-8247/15/7/855

Internet

https://www.mdpi.com/1424-8247/15/7/855

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