Exacerbated response to oxidative stress in the Retinitis Pigmentosa CerklKD/KO mouse model triggers retinal degeneration pathways upon acute light stress

Exacerbated response to oxidative stress in the Retinitis Pigmentosa CerklKD/KO mouse model triggers retinal degeneration pathways upon acute light stress

The retina is particularly vulnerable to genetic and environmental alterations that generate oxidative stress and cause cellular damage in photoreceptors and other retinal neurons, eventually leading to cell death. CERKL (CERamide Kinase-Like) mutations cause Retinitis Pigmentosa and Cone-Rod Dystro...

Full description

Bibliographic Details
Main Authors: Rocío García-Arroyo, Elena B. Domènech, Carlos Herrera-Úbeda, Miguel A. Asensi, Cristina Núñez de Arenas, José M. Cuezva, Jordi Garcia-Fernàndez, Federico V. Pallardó, Serena Mirra, Gemma Marfany
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Redox Biology
Subjects:
CERamide kinase-like
Inherited retinal dystrophies
Oxidative stress
Light injury
Stress response
Retinal degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300263X

Internet

http://www.sciencedirect.com/science/article/pii/S221323172300263X

Similar Items