Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species

Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species

SGLT-2i’s exert direct anti-inflammatory and anti-oxidative effects on resting endothelial cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic stretch. Enhanced stretch increases the production of reactive oxygen species (ROS) and thereby impairs endothelial...

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Bibliographic Details
Main Authors: Xiaoling Li, Gregor Römer, Raphaela P. Kerindongo, Jeroen Hermanides, Martin Albrecht, Markus W. Hollmann, Coert J. Zuurbier, Benedikt Preckel, Nina C. Weber
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
sodium glucose co-transporter 2 inhibitors (SGLT-2i’s)
cell permeability
reactive oxygen species (ROS)
sodium-hydrogen exchanger 1 (NHE1)
NADPH oxidases (NOXs)
Online Access:https://www.mdpi.com/1422-0067/22/11/6044

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https://www.mdpi.com/1422-0067/22/11/6044

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