Design, Synthesis, and Evaluation of <i>B</i>-(Trifluoromethyl)phenyl Phosphine–Borane Derivatives as Novel Progesterone Receptor Antagonists

Design, Synthesis, and Evaluation of <i>B</i>-(Trifluoromethyl)phenyl Phosphine–Borane Derivatives as Novel Progesterone Receptor Antagonists

We previously revealed that phosphine–boranes can function as molecular frameworks for biofunctional molecules. In the present study, we exploited the diversity of available phosphines to design and synthesize a series of <i>B</i>-(trifluoromethyl)phenyl phosphine–borane derivatives as n...

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Bibliographic Details
Main Authors: Yu Miyajima, Kotaro Ochiai, Shinya Fujii
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Molecules
Subjects:
phosphorus
phosphine–borane
hydrophobicity
progesterone receptor
antagonist
structural optimization
Online Access:https://www.mdpi.com/1420-3049/29/7/1587

Internet

https://www.mdpi.com/1420-3049/29/7/1587

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