Enhancing the Therapeutic Effect of 2-<sup>211</sup>At-astato-α-methyl-L-phenylalanine with Probenecid Loading

Enhancing the Therapeutic Effect of 2-<sup>211</sup>At-astato-α-methyl-L-phenylalanine with Probenecid Loading

L-type amino acid transporter 1 (LAT1) might be a useful target for tumor therapy since it is highly expressed in various types of cancers. We previously developed an astatine-211 (<sup>211</sup>At)-labeled amino acid derivative, 2-<sup>211</sup>At-astato-α-methyl-L-phenylala...

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Bibliographic Details
Main Authors: Hirofumi Hanaoka, Yasuhiro Ohshima, Hiroyuki Suzuki, Ichiro Sasaki, Tadashi Watabe, Kazuhiro Ooe, Shigeki Watanabe, Noriko S. Ishioka
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
2-<sup>211</sup>At-astato-α-methyl-L-phenylalanine
targeted alpha therapy
tumor retention
probenecid
blood clearance
Online Access:https://www.mdpi.com/2072-6694/13/21/5514

Internet

https://www.mdpi.com/2072-6694/13/21/5514

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