HIF-1α-Overexpressing Mesenchymal Stem Cells Attenuate Colitis by Regulating M1-like Macrophages Polarization toward M2-like Macrophages

HIF-1α-Overexpressing Mesenchymal Stem Cells Attenuate Colitis by Regulating M1-like Macrophages Polarization toward M2-like Macrophages

A modified mesenchymal stem cell (MSC) transplantation is a highly effective and precise treatment for inflammatory bowel disease (IBD), with a significant curative effect. Thus, we aim to examine the efficacy of hypoxia-inducible factor (HIF)–1α-overexpressing MSC (HIF-MSC) transplantation in exper...

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Bibliographic Details
Main Authors: Wenya Zhu, Qianqian Chen, Yi Li, Jun Wan, Jia Li, Shuai Tang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
mesenchymal stem cells
hypoxia-inducible factor1α
colitis
immunoregulation
macrophages
phosphatidylinositol 3-kinase-γ
Online Access:https://www.mdpi.com/2227-9059/11/3/825

Internet

https://www.mdpi.com/2227-9059/11/3/825

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