Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Enhancing the secretion pathway maximizes the effects of mixed feeding strategy for glucose oxidase production in the methylotrophic yeast Pichia pastoris

Abstract Background A mixed feeding strategy (co-feeding of complex carbon sources with methanol) has become a common practice for process development in Pichia pastoris to increase cell biomass and enzyme production levels. However, in some cases mixed feeding did not have a significant impact or e...

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Bibliographic Details
Main Authors: Olufemi Emmanuel Bankefa, Meiyu Wang, Taicheng Zhu, Yin Li
Format: Article
Language:English
Published: SpringerOpen 2018-05-01
Series:Bioresources and Bioprocessing
Subjects:
Glucose oxidase
Hac1p
Mixed feeding
Pichia pastoris
Secretion pathway engineering
Online Access:http://link.springer.com/article/10.1186/s40643-018-0211-y

Internet

http://link.springer.com/article/10.1186/s40643-018-0211-y

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