Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy.

Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy.

Human aromatase (CYP19A1) is a steroidogenic cytochrome P450 converting androgens into estrogens. No ligand-free crystal structure of the enzyme is available to date. The crystal structure in complex with the substrate androstenedione and the steroidal inhibitor exemestane shows a very compact confo...

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Bibliographic Details
Main Authors: Giovanna Di Nardo, Maximilian Breitner, Sheila J Sadeghi, Silvia Castrignanò, Giampiero Mei, Almerinda Di Venere, Eleonora Nicolai, Paola Allegra, Gianfranco Gilardi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3859599?pdf=render

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http://europepmc.org/articles/PMC3859599?pdf=render

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