Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET<sub>A</sub>R/G<sub>αq</sub>/ERK Signaling Pathway in Human Cardiac Fibroblasts

Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET<sub>A</sub>R/G<sub>αq</sub>/ERK Signaling Pathway in Human Cardiac Fibroblasts

Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast differentiation, which is mainly characterized by an overexpression of α-smooth muscle actin (α-SMA) and collagens. Al...

Full description

Bibliographic Details
Main Authors: Ratchanee Duangrat, Warisara Parichatikanond, Sutharinee Likitnukul, Supachoke Mangmool
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
α-SMA
ambrisentan
bosentan
cardiac fibrosis
collagen
endothelin-1
Online Access:https://www.mdpi.com/1422-0067/24/5/4475

Internet

https://www.mdpi.com/1422-0067/24/5/4475

Similar Items