Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids...

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Bibliographic Details
Main Authors: Huizhen Zhang, Yongtao Wang, Lihuan Guan, Yixin Chen, Panpan Chen, Jiahong Sun, Frank J. Gonzalez, Min Huang, Huichang Bi
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Lipidomics
Lipid accumulation
Lipid peroxidation
Oxidative stress
Mitochondrial dysfunction
Anticancer target
Online Access:http://www.sciencedirect.com/science/article/pii/S209517792030023X

Internet

http://www.sciencedirect.com/science/article/pii/S209517792030023X

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