Development of Robust Varicella Zoster Virus Luciferase Reporter Viruses for In Vivo Monitoring of Virus Growth and Its Antiviral Inhibition in Culture, Skin, and Humanized Mice

Development of Robust Varicella Zoster Virus Luciferase Reporter Viruses for In Vivo Monitoring of Virus Growth and Its Antiviral Inhibition in Culture, Skin, and Humanized Mice

There is a continued need to understand varicella-zoster virus (VZV) pathogenesis and to develop more effective antivirals, as it causes chickenpox and zoster. As a human-restricted alphaherpesvirus, the use of human skin in culture and mice is critical in order to reveal the important VZV genes tha...

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Bibliographic Details
Main Authors: Megan G. Lloyd, Michael B. Yee, Joseph S. Flot, Dongmei Liu, Brittany W. Geiler, Paul R. Kinchington, Jennifer F. Moffat
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
varicella-zoster virus
antiviral drugs
bacterial artificial chromosome
luciferase
bioluminescence imaging
skin organ culture
Online Access:https://www.mdpi.com/1999-4915/14/4/826

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https://www.mdpi.com/1999-4915/14/4/826

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