Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains

Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains

Background: T cells equipped with chimeric antigen receptors (CAR) have shown remarkable efficacy in targeting B lineage malignancies. Improvement of the CAR structure is needed, however, with a view to developing flexibly modifiable spacers that are inert in interactions with unwanted cells. Specif...

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Bibliographic Details
Main Authors: Jan Koski, Farhana Jahan, Annu Luostarinen, Diana Schenkwein, Seppo Ylä-Herttuala, Helka Göös, Hector Monzo, Päivi M. Ojala, Pilvi Maliniemi, Matti Korhonen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Medicine
Subjects:
CAR (chimeric antigen receptor)
spacer
SIRPA
signal regulatory protein alpha
B-ALL
CD19
Online Access:https://www.frontiersin.org/articles/10.3389/fmmed.2022.1049580/full

Internet

https://www.frontiersin.org/articles/10.3389/fmmed.2022.1049580/full

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