Epigenetic regulation of innate immune memory in microglia

Epigenetic regulation of innate immune memory in microglia

Abstract Background Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative slow turnover is that microglia can serve as a long...

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Bibliographic Details
Main Authors: Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Chromatin
Tolerance
Priming
Innate immunity
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-022-02463-5

Internet

https://doi.org/10.1186/s12974-022-02463-5

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