Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells

The intestinal microbiota modulates IL-22 production in the intestine, including the induction of IL-22-producing CD4+ T helper cells. Which specific bacteria are responsible for the induction of these cells is less well understood. Here, we demonstrate through the use of novel gnotobiotic knock-in...

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Bibliographic Details
Main Authors: Urmi Roy, Rômulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
segmented filamentous bacteria (SFB)
cytokine knock-in reporter mice
IL-22
Th22 cells
bystander activation of T cells
Salmonella infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.671331/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.671331/full

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