The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating oligodendrocytes. We show that LMNA/C levels incre...

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Bibliographic Details
Main Authors: Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S. Morioka, Lindsay Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F. Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L. Dupree, Patrizia Casaccia
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008598

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723008598

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