Pre-existing T cell immunity determines the frequency and magnitude of cellular immune response to two doses of mRNA vaccine against SARS-CoV-2

Pre-existing T cell immunity determines the frequency and magnitude of cellular immune response to two doses of mRNA vaccine against SARS-CoV-2

Little is known about the factors associated with lack of T-cell response to mRNA vaccines against SARS-CoV-2. In a prospective cohort of 61 health care workers (HCWs), 21% and 16% after the first dose of mRNA BNT162b vaccine, and 12% and 7% after the second dose, showed lack of CD4+ and CD8+ T-cell...

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Bibliographic Details
Main Authors: José L. Casado, Pilar Vizcarra, Johannes Haemmerle, Héctor Velasco, Adrián Martín-Hondarza, Mario J. Rodríguez-Domínguez, Tamara Velasco, Sara Martín, Beatriz Romero-Hernández, Marina Fernández-Escribano, Alejandro Vallejo
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Vaccine: X
Subjects:
SARS-CoV-2 humoral response
Cellular response
mRNA vaccine
Pre-existing immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136222000250

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http://www.sciencedirect.com/science/article/pii/S2590136222000250

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