Characterization of IncHI1B Plasmids Encoding Efflux Pump TmexCD2-ToprJ2 in Carbapenem-Resistant Klebsiella variicola, Klebsiella quasipneumoniae, and Klebsiella michiganensis Strains

Characterization of IncHI1B Plasmids Encoding Efflux Pump TmexCD2-ToprJ2 in Carbapenem-Resistant Klebsiella variicola, Klebsiella quasipneumoniae, and Klebsiella michiganensis Strains

Tigecycline serves as one of the last-resort antibiotics to treat severe infections caused by carbapenem-resistant Enterobacterales. Recently, a novel plasmid-mediated resistance-nodulation-division (RND)-type efflux pump gene cluster, TmexCD1-ToprJ1, and its variants, TmexCD2-ToprJ2 and TmexCD3-Top...

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Bibliographic Details
Main Authors: Yujiao Wang, Bo Zhu, Min Liu, Xiutao Dong, Jianping Ma, Xiaofeng Li, Fang Cheng, Jianzhuang Guo, Sumei Lu, Furong Wan, Yingying Hao, Wanshan Ma, Mingju Hao, Liang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
TmexCD2-ToprJ2
carbapenem resistance
blaNDM-1
blaNDM-5
Klebsiella variicola
Klebsiella quasipneumoniae
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.759208/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.759208/full

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