Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

Meningitis is a severe form of invasive pneumococcal disease (IPD). To study the contribution of bacterial genomic variation, here Li et al. perform whole genome sequencing of pneumococcal isolates from IPD patients and identify an association for higher risk of meningitis with a pbp1bA641C variant

Bibliographic Details
Main Authors: Yuan Li, Benjamin J. Metcalf, Sopio Chochua, Zhongya Li, Hollis Walker, Theresa Tran, Paulina A. Hawkins, Ryan Gierke, Tamara Pilishvili, Lesley McGee, Bernard W. Beall
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07997-y

Internet

https://doi.org/10.1038/s41467-018-07997-y

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