Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs

Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs

Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulatin...

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Bibliographic Details
Main Authors: Sabina Janciauskiene, Srinu Tumpara, Nils Helge Schebb, Falk F. R. Buettner, Malwina Mainka, Kokilavani Sivaraman, Stephan Immenschuh, Veronika Grau, Tobias Welte, Beata Olejnicka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
alpha-1-antitrypsin
PBMCs
LPS
Interleukin-1β
Cytokines
supernatants
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.995869/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.995869/full

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