LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s disease (AD), with frequent cooccurrence of VCID and...

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Bibliographic Details
Main Authors: Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-04-01
Series:JCI Insight
Subjects:
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.163822

Internet

https://doi.org/10.1172/jci.insight.163822

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