Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection

BackgroundPost-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. However, the underlying mechanisms, especial...

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Bibliographic Details
Main Authors: Yang Liu, Sansan Jia, Jiajia Wang, Dan Wang, Xinxin Zhang, Huiqing Liu, Fang Zhou, Zhihao Zhang, Qi Li, Hailong Dong, Haixing Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1036428/full