The fragile X locus is prone to spontaneous DNA damage that is preferentially repaired by nonhomologous end-joining to preserve genome integrity

The fragile X locus is prone to spontaneous DNA damage that is preferentially repaired by nonhomologous end-joining to preserve genome integrity

Summary: A long CGG-repeat tract in the FMR1 gene induces the epigenetic silencing that causes fragile X syndrome (FXS). Epigenetic changes include H4K20 trimethylation, a heterochromatic modification frequently implicated in transcriptional silencing. Here, we report that treatment with A-196, an i...

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Bibliographic Details
Main Authors: Daman Kumari, Rachel Adihe Lokanga, Cai McCann, Thomas Ried, Karen Usdin
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Human Genetics
Molecular Genetics
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422400035X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422400035X

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