Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

Novel biodegradable and biocompatible formulations of “old” but “gold” drugs such as nystatin (Nys) and amphotericin B (AmB) were made using a biopolymer as a matrix. Medium chain length polyhydroxyalkanoates (mcl-PHA) were used to formulate both polyenes (Nys and AmB) in the form of films (~50 µm)....

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Bibliographic Details
Main Authors: Marina Pekmezovic, Melina Kalagasidis Krusic, Ivana Malagurski, Jelena Milovanovic, Karolina Stępień, Maciej Guzik, Romina Charifou, Ramesh Babu, Kevin O’Connor, Jasmina Nikodinovic-Runic
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antibiotics
Subjects:
polyhydroxyalkanoate
film
antifungal
3-hydroxydecanoic acid
polyene
nystatin
Online Access:https://www.mdpi.com/2079-6382/10/6/737

Internet

https://www.mdpi.com/2079-6382/10/6/737

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